General Information |
|
Product |
PDE4D3 Peptide |
Description |
Antigenic Blocking Peptide cAMP-specific phoshodiesterase HPDE4D3 variant |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant. |
Accession # |
GenBank: EAW74861.1 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Apical cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. |
Structure |
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). |
Alternative Nomenclature |
DPDE3 antibody hPDE4D3 antibody HSPDE4D antibody PDE43 antibody PDE4D antibody PDE4DN2 antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific antibody Phosphodiesterase Type 4D3 antibody STRK1 antibody |
Protein information supplied by UniProt
Fabgennix PDE4D3 Antibody has been used in 3 Publications |
|
Wang, Zhen-Zhen, et al. "Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice." Scientific Reports 5 (2015). PMID26161529
|
Western Blot; Mouse |
Bora, Roop Singh, et al. "A reporter gene assay for screening of PDE4 subtype selective inhibitors." Biochemical and biophysical research communications 356.1 (2007): 153-158. PMID17336928
|
Immunocytochemistry, Western Blot; Human |
Hajjhussein, Hassan et al. “Changes in NMDA Receptor-Induced Cyclic Nucleotide Synthesis Regulate the Age-Dependent Increase in PDE4A Expression in Primary Cortical Cultures.” Brain research 1149 (2007): 58–68. PMC2720317
|
Immunoprecipitation, Western Blot; Human |
Publishing research using PD4D3-431AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PD4D3-431AP | |||
|
PD4D3-FITC | |||
|
PD4D3-BIOTIN | |||
|
PC-PD4D3 | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.