General Information |
|
Product |
SGK3 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Serine/Threonine-protein Kinase Sgk3 Antibody |
Verified Applications |
CM, ELISA, IC, IF, IHC, IP, WB |
Host |
Chicken |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 440-490 on human Sgk3 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.6 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgY |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:100 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:100 |
Immunofluorescence |
1:100 |
Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. |
Molecular Function |
ATP-binding, Nucleotide binding; Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasmic vesicle; Early endosome; Recycling endosome |
Expression |
Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors. |
Structure |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 PX (phox homology) domain. |
Alternative Nomenclature |
CISK antibody Cytokine independent survival kinase antibody DKFZp781N0293 antibody Serine/threonine protein kinase Sgk3 antibody Serum/glucocorticoid regulated kinase family member 3 antibody Serum/glucocorticoid-regulated kinase 3 antibody SGK 3 antibody Sgk3 antibody SGKL antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-SGK3-Y | |||
|
SGK3-301Y | |||
|
SGK3-Y-FITC | |||
|
PC-SGK3 | |||
Display accessory details |
Anti-Chicken Secondary
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