General Information |
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Product |
Natriuretic Peptide Receptor A / PGCA Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Atrial natriuretic peptide receptor 1 Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA.
Seqence:
VRTYWLLGERGCSTRG |
Specificity |
Will label a 127 to 130 kDa protein in various tissues. Will label only PGCA, but not other Particulate Guanylate Cyclases. |
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Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.85 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
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Confocal Microscopy |
1:25-1:250 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:25-1:250 |
Immunofluorescence |
1:25-1:250 |
Immunohistochemistry |
1:25-1:250 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
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Uniprot # |
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Overview |
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
Molecular Function |
ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity |
Subcellular Location |
Membrane; Single-pass type I membrane protein |
Structure |
Homodimer |
Alternative Nomenclature |
ANP A antibody Atrial natriuretic peptide A type receptor antibody Atrial natriuretic peptide receptor 1 antibody GC A antibody GC-A antibody Guanylate cyclase A antibody NPR 1 antibody NPR A antibody |
Protein information supplied by UniProt
Fabgennix PGCA-101AP Antibody has been used in 11 Publications |
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Thompson, Iain R. et al. “Homologous and Heterologous Desensitization of Guanylyl Cyclase-B Signaling in GH3 Somatolactotropes.” Cell and Tissue Research 355.2 (2014): 425–436. PMC3921447
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Confocal Microscopy, Immunofluorescence; Human, Rat |
Watson, Chris J et al. “Mechanical Stretch up-Regulates the B-Type Natriuretic Peptide System in Human Cardiac Fibroblasts: a Possible Defense Against Transforming Growth Factor-β Mediated Fibrosis.”Fibrogenesis & Tissue Repair 5 (2012): 9. PMC3411484
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Confocal Microscopy, Immunofluorescence,Western Blot; Human |
D. Muller, et. al. "Cylic GMP signaling in rat urinary bladder, prostate, and epidiymis: tissue-specific changes with aging and in response to Leydig cell depletion." Journal Society for Reproduction Fertility. 2011 April; 10.1530 PMID21511885
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Western Blot; Rat |
Kotlo, Kumar U., Mark M. Rasenick, and Robert S. Danziger. “Evidence for Cross-Talk Between Atrial Natriuretic Peptide and Nitric Oxide Receptors.”Molecular and cellular biochemistry 338.1-2 (2010): 183–189. PMC2863078
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Confocal Microscopy Immunofluorescence, Immunoprecipitation, Western Blot; Human |
Müller, Dieter, et al. "The Membrane Receptors Guanylyl Cyclase-A And -B Undergo Distinctive Changes In Post-Translational Modification During Brain Development D. Müller Et Al. Guanylyl Cyclase-A And -B Glycosylation In Brain." Journal Of Neurochemistry 115.4 (2010): 1024-1034. PMID20880010
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Western Blot; Mouse, Rat |
Liu, Cambrian Y., Scott E. Fraser, and David S. Koos. "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." Journal of Comparative Neurology 516.1 (2009): 36-48.PMID19565523
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Immunofluorescence, Western Blot; Mouse |
Click Here for the complete list of all FabGennix PGCA Antibody publications
Publishing research using PGCA-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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P-PGCA | |||
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PGCA-101AP | |||
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PGCA-FITC | |||
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PC-PGCA | |||
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