General Information
|
|
Product
|
ErbB 2 Western Blot Positive Control
|
Description
|
Western Blot Positive Control Receptor tyrosine-protein kinase erB-2 isoform b
|
Verified Applications
|
WB
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Storage
|
-20⁰C for long term storage
|
|
Protein
|
Uniprot #
|
P04626
|
Overview
|
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).
|
Molecular Function
|
Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase
|
Subcellular Location
|
Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.
|
Expression
|
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
|
Structure
|
Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with ME
|
Alternative Nomenclature
|
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
c erb B2 antibody
CD340 antibody
cneu antibody
Erb B2 antibody
Erythroblastosis Virus antibody
HER 2 antibody
Herstatin antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
NEU proto oncogene antibody
Neuro Glioblastoma Derived Oncogene Homolog antibody
NGL antibody
p185 ErbB2 antibody
Proto-oncogene Neu antibody
Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody
TKR1 antibody
verbb2 antibody
|
|
|