General Information

Product

Inhibin alpha Antibody

Description

Affinity Purified Inhibin alpha chain Antibody Mixed Epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptides corresponding to amino acid region taken within 1-50 and 220-270 on Inhibin alpha gene.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mixed Epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit antibody

IHA antibody

inhA antibody

INHA_HUMAN antibody

Inhibin alpha chain antibody

Inhibin alpha subunit antibody

General Information

Product

PDE2A3 Antibody

Description

Affinity Purified Phosphodiesterase 2A3 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A3 protein.

Accession #

NCBI:  NP_002590.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Cell membrane; Lipid-anchor

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 3

General Information

Product

PDE2A2 Antibody

Description

Affinity Purified Phosphodiesterase 2A2 Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Mitochondrion matrix

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 2

General Information

Product

PDE2A1 Antibody

Description

Affinity Purified Phosphodiesterase 2A1 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding.

Subcellular Location

Cytoplasm

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 1

General Information

Product

FPR1 Antibody

Description

Affinity Purified N-formyl peptide receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor.

Accession #

GenBank: AAA16863.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21462

Overview

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Molecular Function

N-formyl peptide receptor activity; Receptor activity

Subcellular Location

Cell membrane; Multi-pass membrane

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

fMet Leu Phe receptor antibody

FMLP antibody

FMLPR antibody

Formyl peptide receptor 1 antibody

FPR 1 antibody

FPR receptor antibody

N formyl peptide chemoattractant receptor antibody

N formyl peptide receptor antibody

General Information

Product

SERINC5 Antibody

Description

Affinity Purified Serine incorporator 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 270-320 on human Serine incorporator 5 protein.

Accession #

NCBI:  XP_011541606

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0005D01C8F

Overview

Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Cell membrane; Multi-pass membrane

Expression

Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.

Structure

Belongs to the TDE1 family

Alternative Nomenclature

C5orf12 antibody

SERC5_HUMAN antibody

SERINC5 antibody

Serine incorporator 5 antibody

TPO1 antibody

General Information

Product

SERINC4 Antibody

Description

Affinity Purified Serine incorporator 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human Serine incorporator 4 protein.

Accession #

NCBI: NP_001244960

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A6NH21

Overview

Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Membrane; Multi-ass membrane protein

Structure

Belongs to the TDE1 family

Alternative Nomenclature

FLJ40363 antibody

SERC4_HUMAN antibody

SERINC4 antibody

Serine incorporator 4 antibody

General Information

Product

SERINC1 Antibody

Description

Affinity Purified Serine incorporator 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Pig, Rat

Predicted: Mouse

Immunogen

Synthetic peptide taken within amino acid region 250-310 on human Serine inorporator 1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9NRX5

Overview

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Molecular Function

L-serine transmembrane transporter activity

Subcellular Location

Endoplasmic reticulum membrane

Structure

Belongs to the TDE1 family

Alternative Nomenclature

1500011D18Rik antibody

AI315070 antibody

AIGP 2 antibody

KIAA1253 antibody

LRRGT00191 antibody

mKIAA1253 antibody

SERINC1 antibody

Serine incorporator 1 antibody

TDE1L antibody

TDE2 antibody

TMS 2 antibody

Tumor differentially expressed 1 protein like antibody

Tumor differentially expressed protein 2 antibody

UNQ396/PRO732 antibody