General Information |
|
Product |
BMP2 Peptide |
Description |
Antigenic Blocking Peptide Bone morphogenetic Protein 2 Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide description |
Synthetic peptide corresponding to amino acids within region 340-396 on human Bone morphogenetic Protein 2. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Purification Method |
Immobilized antigen affinity chromatography |
Storage |
-20?C for long term storage |
|
|
Immunodepletion, Immunocompetition |
|
|
|
Uniprot # |
|
Overview |
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). |
Molecular Function |
BMP receptor binding co-receptor binding cytokine activity growth factor activity phosphatase activator activity retinol dehydrogenase activity signaling receptor binding SMAD binding |
Subcellular Location |
Secreted |
Expression |
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. |
Structure |
Belongs to the TGF-beta family. |
Alternative Nomenclature |
BDA2 antibod BMP 2 antibody BMP 2A antibody BMP-2 antibody BMP-2A antibody Bmp2 antibody BMP2_HUMAN antibody BMP2A antibody Bone morphogenetic protein 2 antibody Bone morphogenetic protein 2A antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
BMP-212AP | |||
|
BMP-212-BIOTIN | |||
|
BMP-212-FITC | |||
|
PC-BMP2-212 | |||
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