General Information |
|
Product |
TRPV6 Antibody |
Description |
Affinity Purified Transient receptor potential cation channel, subfamily V, member 6 Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken from the region within amino acids 700-732 of TRPV6 protein. The peptide was covalently modified to acheive desired antigenicity. Modified peptide was covalently coupled to a carrier protein by heterobifunctional cross linker for immunogen preparation. |
Accession # |
GenBank: EAW51899.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.67 µg/µl in antibody stabilization buffer |
Form |
Affinity Purified |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
Molecular Function |
Calcium channel activity; Calmodulin binding |
Subcellular Location |
Cell membrane; Multi-pass membrane protein |
Expression |
Abundantly expressed in pancreas and placenta, and to a much lesser extend in stomach and kidney. Not detected in intestine. |
Structure |
Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmo |
Alternative Nomenclature |
ABPZF antibody Alu binding protein with zinc finger domain antibody Calcium channel CaT1 antibody Calcium transport protein 1 antibody CaT L antibody CaT1 antibody ecac antibody ECaC2 antibody Epithelial apical membrane calcium transporter/channel CaT1 antibody Epithelial calcium channel 2 antibody HSA277909 antibody LP6728 antibody NUDC antibody Transient receptor potential cation channel subfamily V member 6 antibody TrpV6 antibody ZFAB antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
TRPV6-FITC | |||
|
TRPV6-BIOTIN | |||
|
P-TRPV6 | |||
|
PC-TRPV6 | |||
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