General Information
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Product
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ELOVL1 Peptide
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Description
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Antigenic Blocking Peptide Elongation of very long chain fatty acids protein 1
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 148-198 on human Elongation of very long chain fatty acids protein 1.
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Accession #
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NCBI: NP_001243331
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9BW60
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Overview
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Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
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Molecular Function
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Transferase; Fatty acid biosynthesis & metabolism; Lipid biosynthesis & metabolism
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Subcellular Location
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Endoplasmic reticulum membrane; Multi-pass membrane protein
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Expression
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Ubiquitous
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Structure
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The di-lysine motif may confer endoplasmic reticulum localization.
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Alternative Nomenclature
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3 keto acyl CoA synthase ELOVL1 antibody
CGI 88 antibody
Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 1 antibody
Elongation of very long chain fatty acids protein 1 antibody
ELOVL 1 antibody
ELOVL FA elongase 1 antibody
ELOVL fatty acid elongase 1 antibody
ELOVL1 antibody
Ssc1 antibody
Very-long-chain 3-oxoacyl-CoA synthase 1 antibody
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