General Information
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Product
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UBR1 Positive Control
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Description
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Western Blot Positive Control E3 ubiquitin-protein ligase UBR1 Antibody
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Accession |
NP_777576 |
Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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Q8IWV7
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Overview
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E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
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Molecular Function
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Leucine binding; Ubiquitin-protein transferase activity; ligase activity; Zinc ion binding
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Subcellular Location
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Cytosol
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Expression
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Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
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Structure
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The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides.
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Alternative Nomenclature
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E3 ubiquitin-protein ligase UBR1 antibody
JBS antibody
N-recognin-1 antibody
ubiquitin protein ligase E3 component n-recognin 1 antibody
Ubiquitin-protein ligase E3-alpha-1 antibody UBR1 antibody
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