General Information
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Product
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UFD1L Antibody Western Blot Positive Control
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Description
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Western Blot Positive Control UFD1L Purified 20 kDa UFD1L protein Antibody
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Accession #
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GenBank: CAG30493.1
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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Q92890
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Overview
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Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
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Molecular Function
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Ubiquitin-specific protease activity
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Subcellular Location
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Nucleus; Cytosol
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Expression
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Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
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Structure
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Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.
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Alternative Nomenclature
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UB fusion protein 1 antibody
Ubiquitin fusion degradation 1 like (yeast) antibody
Ubiquitin fusion degradation protein 1 homolog antibody
UFD1 antibody
UFD1L antibody
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