General Information |
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Product |
VEGFR1 Positive Control |
Description |
Western Blot Positive Control Vascular Endothelial Growth Factor Receptor 1 |
Verified Applications |
WB |
Immunogen |
Purified Protein |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Concentration | Empircally set for optimal signal-to-noise-ratio. |
Storage |
-20⁰C for long term storage |
Storage Buffer | Preapred in SDS-sample buffer |
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Western Blot |
1:2,500-1:5,000 |
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Uniprot # |
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Overview |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. |
Molecular Function |
Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Isoform 1 :Cell membrane; Single-pass type I membrane protein Endosome Note: Autophosphorylation promotes ubiquitination and endocytosis. Isoform 2 :Secreted Isoform 3 :Secreted Isoform 4 :Secreted Isoform 5 :Cytoplasm Isoform 6 :Cytoplasm Isoform 7 :Cytoplasm |
Expression |
Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). |
Structure |
The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
Alternative Nomenclature |
EC 2.7.10.1 antibody FLT antibody FLT1 antibody Fms like tyrosine kinase 1 antibody Fms related tyrosine kinase 1 antibody Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody FRT antibody Soluble VEGF receptor 1 14 antibody Soluble VEGFR1 variant 2 antibody Soluble VEGFR1 variant 21 antibody Tyrosine protein kinase FRT antibody Tyrosine protein kinase receptor FLT antibody Vascular endothelial growth factor vascular permeability factor receptor antibody Vascular permeability factor receptor 1 antibody VEGFR1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
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VEGFR1-101AP | |||
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VEGFR1-FITC | |||
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VEGFR1-BIOTIN | |||
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P-VEGFR1 | |||
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