General Information |
|
Product |
RIP140 Antibody Mid Region |
Description |
Receptor interacting protein 140 Antibody |
Verified Applications |
CM, ELISA, ICC, IHC, IF, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Chicken, Human, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 50-100, 740-690 or 1050-2000 on mouse receptor interacting protein 140. |
Accession # |
GenBank: AF053062.1 |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.60 µg/µl in antibody stabilization buffer |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:250 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:250 |
Immunofluorescence |
1:250 |
Immunohistochemistry |
1:250 |
Immunoprecipitation |
1:200 |
Western Blot |
1:1,000 |
|
|
Uniprot # |
|
Overview |
Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. |
Molecular Function |
Core promoter sequence-specific DNA binding; Estrogen Receptor binding; Glucocortioid receptor binding; Histone deacetylase binding; Nuclear hormone receptor binding; Receptor binding; Transcription coactivator/corepressor activity |
Subcellular Location |
Nucleus |
Expression |
Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. |
Structure |
Contains at least 4 autonomous repression domains (RD1-4).By similarity Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB. |
Alternative Nomenclature |
NRIP 1 antibody Nuclear factor RIP 140 antibody Nuclear receptor interacting protein 1 antibody Receptor-interacting protein 140 antibodyRIP140 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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RIP140-112AP | |||
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P-RIP140.112 | |||
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RIP140.112-BIOTIN | |||
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PC-RIP140 | |||
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