General Information |
|
Product |
Ephrin Receptor A1 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Ephrin type-A receptor 1 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
Molecular Function |
ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Overexpressed in several carcinomas. |
Structure |
Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA |
Alternative Nomenclature |
EPH antibody EPH receptor A1 antibody Eph tyrosine kinase 1 antibody EphA1 antibody Ephrin receptor Eph A1 antibody Ephrin type-A receptor 1 antibody EPHT 1 antibody Erythropoietin producing hepatoma amplified sequence antibody Esk antibody Esk antibody hEpha1 antibody MGC163163 antibody Oncogene EPH antibody Soluble EPHA1 variant 1 antibody Soluble EPHA1 variant 2 antibody Tyrosine protein kinase receptor EPH antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
EPHAR1-101AP | |||
|
P-EPHAR1 | |||
|
EPHAR1-FITC | |||
|
PC-EPHAR1 | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.