General Information |
|
Product |
Profilin Antibody |
Description |
Affinity Purified Profilin 1 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to amino acids within region 50-100 on human Profilin 1. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
Affinity Purified |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20?C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |
Molecular Function |
actin binding actin monomer binding adenyl-nucleotide exchange factor activity cadherin binding phosphatidylinositol-4,5-bisphosphate binding phosphotyrosine residue binding proline-rich region binding RNA binding |
Subcellular Location |
cytoskeleton |
Expression |
Expressed in epididymis (at protein level). |
Alternative Nomenclature |
Actin binding protein antibody ALS18 antibody Epididymis tissue protein Li 184a antibody OTTHUMP00000125244 antibody PFN 1 antibody Pfn antibody PFN1 antibody PROF1_HUMAN antibody Profilin I antibody Profilin1 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PRFLN-BIOTIN | |||
|
P-PRFLN | |||
|
PRFLN-FITC | |||
|
PC-PRFLN | |||
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