General Information

Product

ARHGEF7 Antibody

Description

Affinity Purified Rho-guanine nucleotide exchange factor 7 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14155

Overview

Acts as RAC1 guanine nucleotide exchange factor and can induce membrane ruffling.

Molecular Function

Neurogenesis

Subcellular Location

Cell junction; foacl adhesion; Cell projection ruffle; Cell cortex

Structure

Interacts with PAK kinases through SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1.

Alternative Nomenclature

ARHG7 antibody

Beta pix antibody

COOL1 antibody

Nbla10314 antibody

P50 antibody

p85 antibody

P85SPR antibody

PAK interacting exchange factor beta antibody

PAK3 antibody

SH3 domain containing proline rich protein antibody

General Information

Product

ARTS Antibody Affinity Purified

Description

Affinity Purified Septin-4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on SEPT4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-075 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43236

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in plate

Alternative Nomenclature

Apoptosis Related Protein TGFb Signalling antibody

ARTS antibody

Bradeion beta antibody

Brain protein H5 antibody

CE5B3 antibody

CE5B3 beta antibody

cell division control-related protein 2 antibody

cerebral protein 7 antibody

H5 antibody

hCDCREL-2 antibody

Hucep 7 antibody

MART antibody

Peanut-like protein 2 antibody

PNUTL2 antibody

SEP4 antibody

SEPT4 antibody

Septin-4 antibody

General Information

Product

ASF1A Antibody

Description

Affinity Purified Histone Chaperone ASF1A Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 60-120 on human AF1A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9Y294

Overview

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Molecular Function

Transcription regulation

Subcellular Location

Nucleus

Structure

Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in cytosolic coplex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP.

Alternative Nomenclature

Anti silencing function 1A antibody

asf1a antibody

CCG1-interacting factor A antibody

CGI 98 antibody

CIA antibody

hAsf1 antibody

hAsf1a antibody

hCIA antibody

Histone chaperone ASF1A antibody

HSPC146 antibody

Hypothetical protein FLJ22085 antibody

General Information

Product

ASNA1 Antibody

Description

Affinity Purified Arsenate activated ATPase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-348 on human ATPase ASNA1 protein.

Accession #

NCBI:  NP_004308

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43681

Overview

ATPase required for post-translational delivery of tail-anchored proteins to the ER

Molecular Function

ATP binding; Metal-binding; Nucleotide binding; Zinc

Subcellular Location

Cytoplasm; Endoplasmic Reticulum; Nucleus

Expression

Epithelial cells of liver, kidney, stomach wall, islet cells of pancreas, red pulp of spleen and cardiac and skeletal muscle.

Structure

Homodimer. Component of transmembrane domain recognition complex.

Alternative Nomenclature

ARSA 1 antibody

ArsA arsenite transporter ATP binding homolog 1 antibody

GET3 antibody

Golgi to ER traffic 3 homolog antibody

Transmembrane domain recognition complex, 40kDa antibody

TRC40 antibody

General Information

Product

D6 Antibody

Description

Affinity Purified Atypical chemokine receptor 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O08707

Overview

Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination.

Molecular Function

Chemokine Receptor activity; Scavenger receptor activity

Subcellular Location

Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein

Expression

Endothelial cells lining afferent lympatics in dermis and lymph nodes.  Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine.

Structure

C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties.

Alternative Nomenclature

ACKR2 antibody

Atypical chemokine receptor 2 antibody

Chemokine binding protein 2 antibody

Chemokine receptor CCR 10 antibody

Chemokine receptor CCR 9 antibody

CMKBR9 antibody

General Information

Product

D6 Antibody 

Description

Affinity Purified Atypical chemokine receptor 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 200-300 on ACRD6 protein.

Accession #

NCBI:  NP_001287.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O00590

Overview

Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination.

Molecular Function

Chemokine Receptor activity; Scavenger receptor activity

Subcellular Location

Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein

Expression

Endothelial cells lining afferent lympatics in dermis and lymph nodes.  Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine.  Experssed in Kapo

Structure

C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties.

Alternative Nomenclature

ACKR2 antibody

Atypical chemokine receptor 2 antibody

Chemokine binding protein 2 antibody

Chemokine receptor CCR 10 antibody

Chemokine receptor CCR 9 antibody

CMKBR9 antibody

General Information

Product

Axin 2 Antibody

Description

Affinity Purified Axis Inhibition Protein 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y2T1

Overview

Inhibitor of Wnt signaling pathway.  Down-regulates beta-catenin.

Molecular Function

Developmental Protein; Wnt signaling pathway

Subcellular Location

Cytoplasm

Expression

Brain and lymphoblast

Structure

Contains 1 DIX domain and 1 RGS domain

Alternative Nomenclature

Axil antibody

Axin like protein antibody

Axis inhibition protein 2 antibody

Conductin antibody

General Information

Product

Axl Antibody

Description

Affinity Purified AXL receptor tyrosine kinase UFO isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 840-880 on mouse AXL protein. The peptide was post translationally modified to acheive proper orientation and antigenicity.

Accession #

NCBI:  NP_033491

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q00993

Overview

Receptor tyrosine kinase that transduces signals from the ECM into cytoplasm by binding growth factor GAS6. Regulates survival, proliferation, migration and differentiation.

Molecular Function

ATP-binding, Nucleotide binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase, Immunity Differentation and Innate Immunity.

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Expression

Developing tissues in late embryogenesis. In cells forming organ capsules as well as in connective tissue structures in adult.

Structure

Heterodimer and heterotetramer with ligand GAS6.

Alternative Nomenclature

Adhesion related kinase 

Ark 

Tyro7 

Tyrosine protein kinase receptor UFO 

General Information

Product

Baboon Antibody

Description

Affinity Purified Baboon Antibody N-epitope

Verified Applications

ELISA, ICC/IF, IP, WB

Species Cross Reactivity

D. melanogaster

Immunogen

N-epitope Synthetic peptide corresponding to amino acid region 200-221 of Drosophila melanogaster protein. The peptide was covalently modified for conjugation.

Synthetic peptide:

CNKNENMKRIFEDYVPHRLTS

Accession #

GenBank:  U04692

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500. Predicted molecular weight: 73 kDa

Protein

Uniprot #

Q23975

Overview

Invovled in activin binding, GPCR kinase activity, serine threonine kinase activity and transforming growth factor beta receptor activity.

Molecular Function

Serine/threonine protein kinase; transferase; ATP and Nucleotide binding

Subcellular Location

Activin receptor complex; Membrane

Structure

Belongs to protein kinase superfamily and contains protein kinase domain.

Alternative Nomenclature

Activin A receptor 45A antibody

ATR1 antibody

Atr45A antibody

Bab antibody

Babo antibody

G protein coupled receptor kinase 3 antibody

Gprk3 antibody

STKE antibody

General Information

Product

Baboon Antibody

Description

Affinity Purified Baboon Antibody C-epitope

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Immunogen

C-epitope Synthetic peptide corresponding to amino acids 552-572 of Drosophila melanogaster Baboon protein. Peptide was covalently modified.

Sequence:

QPDPSIEEMKKVVCIEKCRPN

Accession #

GenBank:  U04692

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q23975

Overview

Invovled in activin binding, GPCR kinase activity, serine threonine kinase activity and transforming growth factor beta receptor activity.

Molecular Function

Serine/threonine protein kinase; transferase; ATP and Nucleotide binding

Subcellular Location

Activin receptor complex; Membrane

Structure

Belongs to protein kinase superfamily and contains protein kinase domain.

Alternative Nomenclature

Activin A receptor 45A antibody

ATR1 antibody

Atr45A antibody

Bab antibody

Babo antibody

G protein coupled receptor kinase 3 antibody

Gprk3 antibody

STKE antibody