DYRK1 Antibody

Product no.: DYRK1-101AP

$285.00

Description

General Information
Product	DYRK1 Antibody
Description	Affinity Purified Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q13627
Overview	May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.
Molecular Function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Subcellular Location	Nucleus speckle
Expression	Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Structure	The polyhistidine repeats act as targeting signals to nuclear speckles.
Alternative Nomenclature	Dual specificity tyrosine phosphorylation regulated kinase Dual specificity YAK1-related kinase DYRK DYRK1 DYRKA hMNB HP86 Minibrain, Drosophila, homolog of MNB MNB protein kinase Mnb protein kinase homolog hp86 MNB protein kinase, Serine/threonine-specific MNB/DYRK protein kinase MNBH MRD7 Protein kinase minibrain homolog Serine/threonine kinase MNB

Protein information supplied by UniProt