General Information
|
|
Product
|
TMEM173 Positive Control
|
Description
|
Western Blot Positive Control Stimulator of interferon genes protein isoform 1
|
Verified Applications
|
WB
|
Immunogen
|
Purified Protein
|
Accession #
|
NCBI: NP_938023
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
86WV6
|
Overview
|
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm.
|
Molecular Function
|
cyclic-di-GMP binding, cyclic-GMP-AMP binding, identical protein binding
|
Subcellular Location
|
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Cytoplasm
|
Expression
|
Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
|
Structure
|
Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.
|
Alternative Nomenclature
|
endoplasmic reticulum IFN stimulator antibody
ERIS antibody
FLJ38577 antibody
Mediator of IRF3 activation antibody
MITA antibody
Mitochondrial mediator of IRF3 activation antibody
MPYS antibody
N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody
NET23 antibody
Stimulator of interferon genes antibody
STING antibody
Tmem173 antibody
Transmembrane protein 173 antibody
|
|
|