General Information

Product

GABA B Receptor 2 Antibody

Description

Affinity Purified Gamma-aminobutyric acid receptor subunit beta-2 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.

Accession #

GenBank: ACY69094.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P47870

Overview

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Molecular Function

Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Expression

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Structure

Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, althoughto different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.

Alternative Nomenclature

GABA-B-R2 antibody

Gamma aminobutyric acid (GABA) B receptor 2 antibody

Gb1 antibody

GPRC3A antibody

Seven transmembrane helix receptor antibody

General Information

Product

MERTK Antibody

Description

Affinity Purified Human cellular proto-oncogene (c-mer) Antibody Mid-Region

Verified Applications

CM, ELISA, Flow Cytometry, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide:

VQETKFGGAFSEEDC

corresponding to amino acid region 524-537 on Rat MERTK protein.

Accession #

NCBI:  NP_075232

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:750

Protein

Uniprot #

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Is expressed in many neoplastic B- and T-cells.  Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.

Structure

Interacts with TNK2 upon activation.  Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase antibody

Eyk antibody

MER antibody

MER receptor tyrosine kinase antibody

MERK antibody

MERPEN antibody

Mertk antibody

MERTK c-mer proto-oncogene tyrosine kinase antibody

MGC133349 antibody

nmf12 antibody

Nyk antibody

Proto oncogene tyrosine protein kinase MER antibody

Proto-oncogene c-Mer antibody

Receptor tyrosine kinase MerTK antibody

RP38 antibody

STK kinase antibody

Tyrosine-protein kinase Mer antibody

General Information

Product

MERTK Antibody

Description

Affinity Purified Human cellular proto-oncogene (c-mer) mRNA Antibody C-epitope

Verified Applications

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-994 on MerTK protein.

Accession #

NCBI:  NP_075232

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:750-1:2,000

Protein

Uniprot #

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Is expressed in many neoplastic B- and T-cells.  Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.

Structure

Interacts with TNK2 upon activation.  Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase antibody

Eyk antibody

MER antibody

MER receptor tyrosine kinase antibody

MERK antibody

MERPEN antibody

Mertk antibody

MERTK c-mer proto-oncogene tyrosine kinase antibody

MGC133349 antibody

nmf12 antibody

Nyk antibody

Proto oncogene tyrosine protein kinase MER antibody

Proto-oncogene c-Mer antibody

Receptor tyrosine kinase MerTK antibody

RP38 antibody

STK kinase antibody

Tyrosine-protein kinase Mer antibody

General Information

Product

MERTK Antibody

Description

Affinity Purified Human cellular proto-oncogene (c-mer) mRNA Antibody N-epitope

Verified Applications

CM, ELISA, Flow Cytometry, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on MerTK protein.

Accession #

NCBI:  NP_075232

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:750

Protein

Uniprot #

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Is expressed in many neoplastic B- and T-cells.  Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.

Structure

Interacts with TNK2 upon activation.  Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase antibody

Eyk antibody

MER antibody

MER receptor tyrosine kinase antibody

MERK antibody

MERPEN antibody

Mertk antibody

MERTK c-mer proto-oncogene tyrosine kinase antibody

MGC133349 antibody

nmf12 antibody

Nyk antibody

Proto oncogene tyrosine protein kinase MER antibody

Proto-oncogene c-Mer antibody

Receptor tyrosine kinase MerTK antibody

RP38 antibody

STK kinase antibody

Tyrosine-protein kinase Mer antibody

General Information

Product

ELOVL4 Antibody

Description

Affinity Purified Elongation of very long chain fatty acids protein 4 Antibody

N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Cat, Rat

Immunogen

Synthetic peptide corresponding to amino acids 2-22 of Human ELOVL4 protein.

Sequence:

GLLDSEPGSVLNVVSTALNDT

Accession #

NCBI:  NP_073563

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q9GZR5

Overview

Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development.

Molecular Function

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Subcellular Location

Endoplasmic Reticulum; Membrane

Expression

Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.

Structure

The di-lysine motif may confer endoplasmic reticulum localization.

Alternative Nomenclature

3-keto acyl-CoA synthase ELOVL4 antibody

ADMD antibody

Cancer/testis antigen 118 antibody

CT118 antibody

Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 4 antibody

ELOV L4 antibody

Stargardt disease 3 antibody

STGD2 antibody

STGD3 antibody

General Information

Product

MRAP2 Antibody

Description

Affinity Purified Melanocortin-2 receptor accessory protein Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 70-120 on mouse Melanocortin-2 receptor accessory protein.

Accession #

NCBI:  AY079153

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Dot blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9D159

Overview

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

Molecular Function

Brown fat cell differentiation; Positive regulation of cAMP biosynthetic process; Protein localization to cell surface

Subcellular Location

Single-pass membrane protein; Endoplasmic Reticulum membrane

Expression

Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.

Structure

Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.

Alternative Nomenclature

bA51G5.2 antibody

BMIQ18 antibody

C6orf117 antibody

MC2R accessory protein 2 antibody

Melanocortin-2 receptor accessory protein 2 antibody

General Information

Product

MRAP2 Antibody Affinity Purified

Description

Affinity Purified Melanocortin-2 receptor accessory protein Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Predicted: Human

Immunogen

Synthetic peptide taken within amino acid region 1-50 on mouse Melanocortin-2 receptor accessory protein.

Accession #

NCBI:  AY079153

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DOT blot

1:10,000

ELISA

1:10,000

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9D159

Overview

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).

Molecular Function

Brown fat cell differentiation; Positive regulation of cAMP biosynthetic process; Protein localization to cell surface

Subcellular Location

Single-pass membrane protein; Endoplasmic Reticulum membrane

Expression

Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.

Structure

Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R (By similarity).

Alternative Nomenclature

bA51G5.2 antibody

BMIQ18 antibody

C6orf117 antibody

MC2R accessory protein 2 antibody

Melanocortin-2 receptor accessory protein 2 antibody

General Information

Product

Soluble Adenylate Cyclase 1 Antibody

Description

Affinity Purified Soluble adenylyl cyclase brain isoform, partial Antibody Mid-Region

Verified Applications

CM, ELISA, ICC, IHC, IF, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on SAC protein.

Accession #

GenBank: ACA47266.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

B1PMG2

Molecular Function

adenylate cyclase activity

Subcellular Location

Cytoplasm, membrane

Alternative Nomenclature

Adcy1 antibody

adenyl cyclase antibody

ATP pyrophosphate lyase antibody

Brain adenylate cyclase 1 antibody

Ca(2+)/calmodulin-activated adenylyl cyclase antibody

General Information

Product

Soluble Adenylate Cyclase 1 Antibody

Description

Affinity Purified Soluble adenylyl cyclase brain isoform, partial Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on SAC protein.

Accession #

GenBank: ACA47266.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

B1PMG2

Molecular Function

adenylate cyclase activity

Subcellular Location

Cytoplasm, membrane

Alternative Nomenclature

Adcy1 antibody

adenyl cyclase antibody

ATP pyrophosphate lyase antibody

Brain adenylate cyclase 1 antibody

Ca(2+)/calmodulin-activated adenylyl cyclase antibody

General Information

Product

Soluble Adenylate Cyclase 1 Antibody

Description

Affinity Purified Soluble adenylyl cyclase brain isoform, partial Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on SAC protein.

Accession #

GenBank: ACA47266.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

B1PMG2

Molecular Function

adenylate cyclase activity

Subcellular Location

Cytoplasm, membrane

Alternative Nomenclature

Adcy1 antibody

adenyl cyclase antibody

ATP pyrophosphate lyase antibody

Brain adenylate cyclase 1 antibody

Ca(2+)/calmodulin-activated adenylyl cyclase antibody