General Information |
|
Product |
PDE4A Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Pan Phosphodiesterase 4A Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Moose, Mouse, Rat |
Immunogen |
Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins. |
Specificity | This antibody labels all known PDE4A variants including PDE4A1 (66 kDa), PDE4A5 (109 kDa), PDE4A8 (106 kDa), AND PDE4Ax (10 kDa) and a 76 kDa testis specific A variant. |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
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|
Confocal Microscopy |
1:100-1:400 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:100-1:400 |
Immunofluorescence |
1:100-1:400 |
Immunohistochemistry |
1:100-1:400 |
Immunoprecipitation |
1:250 |
Western Blot |
1:1,000-1:2,500 |
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Uniprot # |
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Overview |
Hydrolyzes the second messenger cAMP which is a key regulator of many important physiological processes. |
Molecular Function |
cAMP |
Subcellular Location |
Isoform 1: perinuclear region, Isoform 2: ruffle membrane, Isoform 4: Peripheral membrane protein, Isoform 6: perinuclear region, Isoform 7: Membrane, Cytoplasm |
Expression |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressedi n the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). |
Structure |
Belongs to cyclic nucleotide phosphodiesterase family. PDE4 subfamily |
Alternative Nomenclature |
5''-cyclic phosphodiesterase 4A antibody cAMP specific 3 5 cyclic phosphodiesterase 4A antibody DPDE2 antibody dunce like phosphodiesterase E2 antibody PDE 4A antibody PDE4 antibody PDE46 antibody PDE4A11 antibody Phosphodiesterase 4A antibody phosphodiesterase 4A cAMP specific antibody phosphodiesterase E2 dunce homolog antibody phosphodiesterase isozyme 4 antibody phosphodiesterase type 4A11 antibody |
Protein information supplied by UniProt
Fabgennix PDE4A Antibody has been used in 44 Publications |
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Immunohistochemistry, Western Blot; Human |
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Immunohistochemistry; Human |
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Western Blot; Mouse |
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Western Blot; Rat |
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Western Blot; Mouse |
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Western Blot; Mouse |
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Immunocytochemistry, Western Blot; Human |
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Confocal Microscopy, Immunofluorescence, Immunohistochemistry, Western Blot; Rat |
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Western Blot; Rat |
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Immunocytochemistry, Western Blot; Human |
Publishing research using PD4A-112AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PD4A | |||
|
PD4A-112AP | |||
|
PD4A-FITC | |||
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PC-PD4A | |||
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