General Information |
|
Product |
CDKN2A / p14ARF Antibody BIOTIN |
Description |
BIOTIN-Conjugated partial tumor supressor p14ARF Antibody Mid-Region |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Mid-Region epitope synthetic peptide corresponding to unique amino acid sequence on p14ARF protein |
Accession # |
GenBank: AAC6069.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
1.00-1.25 mg/ml µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
Mid-Region |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Functions as a tumor supressor and has the ability to induce cell cycle arrest in the G1 and G2 phases. Serves to induce G2 arrest and apoptosis in a p53-independent manner via preventing the activation of cyclin B1/CDC2 complexes. |
Molecular Function |
DNA binding, RNA binding, p53 binding, MDM2/MDM4 family protein binding |
Subcellular Location |
Nucleus |
Structure |
No interaction with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Interacts with TBRG1, COMMD1, CDKN2AIP and E4F1. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. |
Alternative Nomenclature |
ARF antibody CDK4 inhibitor p16 INK4 antibody CDK4I antibody CDKN 2A antibody Cell cycle negative regulator beta antibody CMM2 antibody Cyclin dependent kinase 4 inhibitor A antibody 1/2/3 antibody Cyclin dependent kinase inhibitor p16 antibody INK4 antibody Melanoma p16 inhibits CDK4 antibody MLM antibody MTS 1 antibody p14 antibody p16 antibody p19 antibody P19ARF antibody TP16 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-P14ARF.110 | |||
|
P14ARF-112AP | |||
|
P14ARF.110-FITC | |||
|
PC-P14ARF | |||
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