General Information |
|
Product |
UBR1 Antibody FITC |
Description |
FITC-Conjugated E3 ubiquitin-protein ligase UBR1 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1260-1500 on human UBR1 protein. |
Accession | NP_777576 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.68-0.70 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:4,000 |
ELISA |
1:4,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
Molecular Function |
Leucine binding; Ubiquitin-protein transferase activity; ligase activity; Zinc ion binding |
Subcellular Location |
Cytosol |
Expression |
Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). |
Structure |
The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif. The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides. |
Alternative Nomenclature |
E3 ubiquitin-protein ligase UBR1 antibody JBS antibody N-recognin-1 antibody ubiquitin protein ligase E3 component n-recognin 1 antibody Ubiquitin-protein ligase E3-alpha-1 antibody UBR1 antibody |
Protein information supplied by UniProt
To view the Specification Sheet for UBR1 Antibody, click the link below:
Product | Note | Status | Price | |
---|---|---|---|---|
|
UBR1-101AP | |||
|
P-UBR1 | |||
|
UBR1-BIOTIN | |||
|
PC-UBR1 | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.