Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Subcellular Location
Plasma membrane
Expression
Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Structure
Transmembrane, Transmembrane helix
Alternative Nomenclature
Solute Carrier Family 26 Member 3
DRA
Solute Carrier Family 26 (Anion Exchanger), Member 3