ITPR2 Blocking Peptide

General Information

Product

ITPR2 Peptide

Description

Antigenic Blocking Peptide Inositol 1,4,5-triphosphate receptor type 2

Verified Applications

Immmunodepletion, Competition Assay

Peptide Description

Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1,4,5-triphosphate receptor type 2 protein.

Accession #

NCBI:  NP_112308

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P29995

Overview

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

Molecular Function

Calcium ion binding; inositol 1,4,5-triphosphate binding; cellular response to hypoxia; Transport

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Isoform Short is found in skeletal muscle and heart.

Structure

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Alternative Nomenclature

4 antibody

5-trisphosphate receptor antibody

Inositol 1 4 5 trisphosphate receptor type 2 antibody

InsP3R2 antibody

IP3 R2 antibody

IP3 receptor antibody

IP3 receptor isoform 2 antibody

IP3R 2 antibody

ITPR 2 antibody

Type 2 inositol 1 4 5 trisphosphate receptor antibody

Type 2 inositol 1 antibody

Type 2 InsP3 receptor antibody