General Information
|
|
Product
|
Cell Surface Glycoprotein MUC18 Antibody BIOTIN
|
Description
|
BIOTIN-Conjugated Cell Surface Glycoprotein MUC18 Antibody
|
Verified Applications
|
ELISA, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Rat
|
Immunogen
|
Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein.
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.5-1.5 µg/µl in antibody stabilization buffer
|
Immunoglobulin
|
IgG
|
Form
|
BIOTIN-Conjugated
|
Purification Method
|
Immobilized antigen affinity chromatography
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
ELISA
|
1:50,000
|
Immunoprecipitation
|
1:200
|
Western Blot
|
1:2,500-1:5,000
|
Protein
|
Uniprot #
|
Q9EPF2
|
Overview
|
lays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
|
Subcellular Location
|
Cell membrane; Single-pass type I membrane protein
|
Expression
|
Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level).
|
Structure
|
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix
|
Alternative Nomenclature
|
A32 antigen antibody
CD 146 antibody
Cell surface glycoprotein MUC18 antibody
Cell surface glycoprotein P1H12 antibody
Gicerin antibody
Mcam antibody
Melanoma adhesion molecule antibody
Melanoma associated antigen A32 antibody
Melanoma associated antigen MUC18 antibody
Melanoma associated glycoprotein MUC18 antibody
MelCAM antibody
MUC 18 antibody
S endo 1 antibody
S endo 1 endothelial associated antigen antibody
|
|
|