General Information |
|
Product |
Eprhin Receptor B3 Peptide |
Description |
Antigenic Blocking Peptide Ephrin type-B receptor 3 precursor Antibody |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic Peptide |
Accession # |
NCBI: NP_034273 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. |
Molecular Function |
ATP-binding, Nucleotide-binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein; Early endosome membrane; Dendrite |
Expression |
Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level). |
Structure |
Contains 1 Eph LBD domain; Contains 2 fibronectin type-III domains; Contains 1 protein kinase domain; Contains 1 SAM domain |
Alternative Nomenclature |
Cek10 antibody EK2 antibody Embryonic kinase 2 antibody EPH Like Tyrosine Kinase 2 antibody EPH receptor B3 antibody EPH-like kinase 2 antibody ephb3 antibody Ephrin type-B receptor 3 antibody ETK2 antibody hEK2 antibody Human Embryo Kinase 2 antibody Mdk5 antibody Sek4 antibody TYRO6 antibody Tyrosine protein kinase receptor HEK2 antibody Tyrosine-protein kinase TYRO6 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
EPHBR3-301AP | |||
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EPHBR3-FITC | |||
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EPHBR3-BIOTIN | |||
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PC-EPHBR3 | |||
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