General Information |
|
Product |
GSK3 beta Peptide |
Description |
Antigenic Blocking Peptide Glycogen Synthase Kinase-3 beta |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic peptide taken within amino acid region 1-50 on human GSK3 beta protein. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Immunoglobulin |
IgY |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Immunohistochemistry | 1:100 |
Competition/Depletion assay |
1:500 |
|
|
Uniprot # |
|
Overview |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. |
Molecular Function |
Developmental protein, Kinase, Serine/threonine-protein kinase, Signal tranduction inhibitor, Transferase |
Subcellular Location |
Cytoplasm; Nucleus; Cell membrane |
Expression |
Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. |
Structure |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. Contains 1 protein kinase domain. |
Alternative Nomenclature |
Glycogen Synthase Kinase 3 Beta antibody GSK 3 beta antibody Serine/threonine-protein kinase GSK3B antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
GSK3B-301Y | |||
|
GSK3B-Y-FITC | |||
|
GSK3B-Y-BIOTIN | |||
|
PC-GSK3B | |||
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