General Information |
|
Product |
WWOX 1/4 Antibody Western Blot Positive Control |
Description |
Western Blot Positive Control WW domain-containing Oxidoreductase isoform 1 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_057457.1 |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
Molecular Function |
Coenzyme binding; protein dimerization activity; cofactor binding; |
Subcellular Location |
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus |
Expression |
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
Structure |
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. |
Alternative Nomenclature |
D16S432E antibody FOR antibody FOR II protein antibody FRA16D antibody fragile 16D oxido reductase antibody fragile site FRA16D oxidoreductase antibody HHCMA56 antibody PRO0128 antibody putative oxidoreductase antibody WW domain-containing oxidoreductase antibody WW domain-containing protein WWOX antibody WWOX antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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WWOX1-101AP | |||
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WWOX1-FITC | |||
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WWOX1-BIOTIN | |||
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P-WWOX1 | |||
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