General Information |
|
Product |
MAPK9 Positive Control |
Description |
Western Blot Positive Control Mitogen-activated protein kinase 9 Antibody |
Verified Applications |
WB |
Immunogen |
Purified protein |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Nucleus |
Structure |
Interacts with MECOM and DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with BCL10. Interacts with CTNNB1 and GSK3B. |
Alternative Nomenclature |
c Jun kinase 2 antibody JNK 55 antibody JNK2 alpha antibody JNK2 antibody JNK2 beta antibody Jun kinase antibody MAP kinase 9 antibody P54a antibody p54aSAPK antibody PRKM9 antibody SAPK alpha antibody Stress activated protein kinase 1a antibody Stress-activated protein kinase JNK2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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MAPK9-101AP | |||
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MAPK9-BIOTIN | |||
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MAPK9-FITC | |||
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P-MAPK9 | |||
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