General Information

Product

AIM2 Antibody

Description

Affinity Purified Interferon-inducible protein AIM2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.

Accession #

NCBI:  NP_004824

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14862

Overview

Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages.  Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Molecular Function

Apoptosis, Immunity, Inflammatory response, Innate Immunity

Expression

Expressed in spleen, small intestine, peripheral blood leukocytes and testis. 

Structure

Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.

Alternative Nomenclature

Absent in melanoma 2 antibody

PYHIN4 antibody

General Information

Product

DCC Antibody

Description

Affinity Purified Netrin Receptor DCC Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43146

Overview

Receptor for netrin required for axon guidance; may trigger signaling for axon repulsion; acts as a dependence receptor required for apoptosis induction; tumor suppressor gene.

Molecular Function

netrin receptor activity; transcription coactivator activity; transmembrane signaling receptor activity; Developmental protein

Subcellular Location

axon; cytosol; plasma membrane

Expression

Found in axons of the central and peripheral nervous system; differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family; Contains 6 fibronectin type-III domains; Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

Colorectal cancer related chromosome sequence 18 antibody

CRC 18 antibody

CRCR 1 antibody

DCC antibody

Deleted in colorectal cancer protein antibody

Immunoglobulin superfamily DCC subclass member 1 antibody

Netrin receptor DCC antibody

Tumor suppressor protein DCC antibody

General Information

Product

FYN Antibody

Description

Affinity Purified Fyn Tyrosine Kinase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 240-290 on human Fyn protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q96AE4

Molecular Function

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cytoplasm; Nucleus; Cell membrane

Expression

Isoform 1 is expressed in the brain, and Isoform 2 is expressed in cells of hemopoietic lineages.

Structure

Interacts with PIK3R1,PRMT8,FYB, PAG1, SH2D1A, CD79A.  Also interacts with HEV ORF3 protein, ITCH, RUNX3, KIT, PTK1/FAK1, CAV1, UNC119 and EPHA8.

Alternative Nomenclature

C syn protooncogene antibody

Fyn antibody

FYN oncogene related to SRC FGR YES antibody

OKT3 induced calcium influx regulator antibody

P59 FYN antibody

Proto oncogene tyrosine protein kinase fyn antibody

Proto-oncogene c-Fyn antibody

Proto-oncogene Syn antibody

SLK antibody

Src yes related novel gene antibody

Src-like kinase antibody

SYN antibody

Tyrosine kinase p59fyn(T) antibody

Tyrosine-protein kinase Fyn antibody

General Information

Product

G0/G1 switch 2 Antibody

Description

Affinity Purified Lymphocyte G0/G1 Switch protein 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 78-103 on mouse G0S2-like protein. The peptide was covalently modified to achieve desired antigenicity and conjugated to a carrier protein.

Sequence:

ALLAGGKAQEATLCSRALSLRQHAS

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500 Predicted molecular weight: 11 kDa.

Protein

Uniprot #

Q68515

Subcellular Location

Mitochondrion

Structure

Interacts directly with BCL2; which prevents the formation of the anti-apoptotic BAX-BCL2 complex.

Alternative Nomenclature

G0/G1 switch regulatory protein 2 antibody

OTTHUMP00000034644 antibody

Putative lymphocyte G0/G1 switch protein 2 antibody

RP1 28O10.2 antibody

General Information

Product

GADD45B Antibody

Description

Affinity Purified Negative growth regulatory protein Antibody

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-160 on mouse GADD45b protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P22339

Overview

Acts in the regulation of growth and apoptosis.  Also mediates the activation of stress-responsive MTK1/MEKK4 MAPKKK.

Molecular Function

Developmental protein

Subcellular Location

Cytoplasm

Expression

Expressed in myeloid precursor enriched BM cells

Structure

Interacts with GADD45GIP2

Alternative Nomenclature

GADD45 Beta antibody

Growth arrest and DNA damage-inducible gene GADD45, beta antibody

MYD118, mouse, homolog of antibody

Myeloid differentiation primary response protein MyD118 antibody

Negative growth regulatory protein MyD118 antibody

General Information

Product

PALB2 Antibody

Description

Affinity Purified Partner and localizer of BRCA2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1,130-1,186 on human PALB2 protein.

Accession #

GenBank: AAH44254.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q86YC2

Molecular Function

DNA binding

Subcellular Location

Nucleus

Structure

Homooliomer; dissociated once DNA damage has occurred which allows association with BRCA1.

Alternative Nomenclature

4732427B05 antibody

BC066140 antibody

DKFZp667I166 antibody

DKFZp686E1054 antibody

FANCN antibody

FLJ21816 antibody

OTTMUSP00000025884 antibody

PALB2 antibody

Partner and localizer of BRCA2 antibody

PNCA3 antibody

RGD1304759 antibody

General Information

Product

Prominin 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Human Prominin 2 amino acids 315-338. 

Sequence:

RTLELGADFSQVPSVDHVLHQLKG

Accession #

NCBI:  NP_653308.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:2,000

ELISA

1:2,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8N271

Molecular Function

Cholesterol binding

Subcellular Location

Apical cell membrane, multi-pass membrane protein (Note: Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells).

Expression

Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.

Alternative Nomenclature

MGC138714 antibody

PROM 2 antibody

Prominin like protein 2 antibody

Prominin related protein antibody

Prominin-2 antibody

General Information

Product

Robo3 Antibody Affinity Purified

Description

Affinity Purified Homer protein homolog 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human RIG1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Z214

Overview

ostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.

Molecular Function

G-protein coupled glutamate receptor binding, identical protein binding, receptor binding

Subcellular Location

Cytoplasm, Cell junction

Expression

Highly expressed in cortex, Purkinje cells of the cerebellum, hippocampus, striatum and olfactory bulb. Isoform 1and isoform 3 are expressed in skeletal and cardiac muscle.

Structure

Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Alternative Nomenclature

HGPPS antibody

HGPS antibody

RB inhibiting gene 1 antibody

Rbig1 antibody

Retinoblastoma inhibiting gene 1 antibody

Rig1 antibody

Roundabout axon guidance receptor homolog 3 antibody

Roundabout like protein 3 antibody

General Information

Product

RUNX1 / AML1 Antibody Affinity Purified

Description

Affinity Purified RUNX1 Protein Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-80 on human RUNX1 protein.

Accession #

GenBank: AAI36381.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q01196

Overview

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis.

Molecular Function

ATP binding, DNA binding, calcium ion binding

Subcellular Location

Nucleus

Expression

Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.

Structure

Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize.

Alternative Nomenclature

Acute myeloid leukemia 1 protein antibody

alpha subunit core binding factor antibody

AML1 EVI 1 fusion protein antibody

Aml1 oncogene antibody

AMLCR 1 antibody

CBF alpha 2 antibody

Core binding factor runt domain alpha subunit 2 antibody

Core-binding factor subunit alpha-2 antibody

EVI1 antibody

HGNC antibody

Oncogene AML 1 antibody

PEBP2 alpha B antibody

Polyomavirus enhancer binding protein 2 alpha B subunit antibody

Run1 antibody

Runt-related transcription factor 1 antibody

SL3/AKV core binding factor alpha B subunit antibody

General Information

Product

SESN3 Antibody Affinity Purified

Description

Affinity Purified SESN3 protein Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on SESN3 protein.

Accession #

GenBank: AAH17296.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.80 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P58005

Subcellular Location

Nucleus

Expression

Widely expressed.

Alternative Nomenclature

SEST3 antibody
Sestrin 3 antibody