General Information
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Product
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Protein Vestigial Peptide
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide
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Accession #
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NCBI: NP_523723.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q26366
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Overview
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Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr, may control genes involved in DNA replication.
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Molecular Function
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DNA binding; Protein C-terminus binding
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Subcellular Location
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Nucleus
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Expression
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Expressed in the developing wing primordia initially along the D/V wing boundary, and by the late third larval instar, maximal expression is seen in cells at the D/V wing disk boundary. Less expression is seen in cells located farther from this boundary.
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Alternative Nomenclature
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VG
VSTGL
VG21
DMEL/CG3830
CCG3830
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