General Information
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Product
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TMEM16A Peptide
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Description
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Antigenic Blocking Peptide Transmembrane protein 16A Antibody C-epitope
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Verified Applications
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Immunocompeition, Immunodepletion
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Peptide Description
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Synthetic Peptide
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q5XXA6
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Overview
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Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
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Molecular Function
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Chloride channel, Developmental protein, Ion channel
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Subcellular Location
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Cell membrane; Multi-pass membrane protein, Cytoplasm
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Expression
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Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
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Structure
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Homodimer. Interacts with CFTR (By similarity).
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Alternative Nomenclature
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ANO 1 antibody
Anoctamin 1 antibody
Anoctamin 1 calcium activated chloride channel antibody
Ca2+ activated Cl- channel antibody
Discovered on gastrointestinal stromal tumors protein 1 antibody
DOG 1 antibody
Membrane protein antibody
Oral cancer overexpressed protein 2 antibody
ORAOV 2 antibody
TAOS2 antibody
Transmembrane protein 16A antibody
Tumor-amplified and overexpressed sequence 2 antibody
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