General Information |
|
Product |
PDE11A Peptide |
Description |
Antigenic Blocking Peptide Cyclic Nucleotide Phosphodiesterase 11A1 C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 420-480 on PDE11A protein, common to all PDE11A variants. |
Accession # |
GenBank: CAB82573.1 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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|
Uniprot # |
|
Overview |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
Molecular Function |
Hydrolase, metal-ion binding, cGMP binding |
Subcellular Location |
Cytoplasm |
Expression |
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. |
Alternative Nomenclature |
5''-cyclic-AMP and -GMP phosphodiesterase 11A cAMP and cGMP cyclic nucleotide phosphodiesterase 11A Cyclic nucleotide phosphodiesterase 11A1 Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A PDE 11A pde11 pde11a2 Phosphodiesterase 11A PPNAD2 |
Protein information supplied by UniProt
Fabgennix PDE11A Antibody has been used in 14 Publications |
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Western Blot; Rat |
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Immunohistochemistry, Immunocompetition; Human |
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Western Blot Immunocompetition; Human, Mouse |
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Western Blot; Human |
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Immunohistochemistry; Human |
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Immunofluorescence, Western Blot; Rat |
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Immunohistochemistry; Human |
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Western Blot; Mouse |
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Immunohistochemistry, Immunodepletion, Western Blot; Rat |
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Immunofluorescence; Human |
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Immunofluorescence, Immunohistochemistry; Human |
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Immunohistochemistry, Western Blot; Human |
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Immunofluorescence, Western Blot; Mouse |
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Immunohistochemistry, Western Blot; Human |
Publishing research using PD11A-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PD11A-112AP | |||
|
PD11A.112-FITC | |||
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PD11A.112-BIOTIN | |||
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PC-PD11A | |||
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