General Information |
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Product |
Natriuretic Peptide Receptor B / PGCB Antibody FITC-Conjugated |
Description |
FITC-Conjugated Atrial natriuretic peptide receptor 2 Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein. |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.75-1.20 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
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|
Confocal Microscopy |
1:200 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:200 |
Immunofluorescence |
1:50-1:200 |
Immunohistochemistry |
1:200 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
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Uniprot # |
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Overview |
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. |
Molecular Function |
ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity |
Subcellular Location |
Membrane; Single-pass type I membrane protein |
Structure |
Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain. |
Alternative Nomenclature |
AMDM antibody ANPB antibody ANPRB antibody peptide receptor type B antibody Atrionatriuretic peptide receptor B antibody GC-B antibody GUCY2B antibody Natriuretic peptide receptor B/guanylate cyclase B antibody NPR-B antibody NPR2 antibody NPRBi antibody |
Protein information supplied by UniProt
Fabgennix PGCB Antibody has been used in 8 Publications |
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Immunocytochemistry, Immunohistochemistry, Confocal Microscopy; Rat
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Thompson, Iain R. et al. “Homologous and Heterologous Desensitization of Guanylyl Cyclase-B Signaling in GH3 Somatolactotropes.” Cell and Tissue Research 355.2 (2014): 425–436. PMC3921447
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Confocal Microscopy, Immunofluorescence, Western Blot; Human, Rat
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Thong, Arief, et al. "Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells–Its relevance for CNP degradation." Molecular and cellular endocrinology 382.1 (2014): 234-243. PMID24099862
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Immunofluorescence, Western Blot; Human, Mouse
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D. Muller, et. al. "Cylic GMP signaling in rat urinary bladder, prostate, and epidiymis: tissue-specific changes with aging and in response to Leydig cell depletion." Journal Society for Reproduction Fertility. 2011 April; 10.1530 PMID21511885
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Western Blot; Rat |
Müller, Dieter, et al. "The Membrane Receptors Guanylyl Cyclase-A And -B Undergo Distinctive Changes In Post-Translational Modification During Brain Development D. Müller Et Al. Guanylyl Cyclase-A And -B Glycosylation In Brain." Journal Of Neurochemistry 115.4 (2010): 1024-1034.
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Western Blot; Mouse, Rat |
Liu, Cambrian Y., Scott E. Fraser, and David S. Koos. "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." Journal of CompaRative Neurology 516.1 (2009): 36-48. PMID19565523
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Immunofluorescence, Western Blot; Mouse
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Thompson, Iain R., et al. "Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, αT3-1 and LβT2 gonadotroph cells." Journal of Endocrinology 203.2 (2009): 215-229 PMID19666697
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Western Blot; Mouse |
Zhu, Bing, Samuel Strada, and Troy Stevens. "Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 289.2 (2005): L196-L206. PMID15792963
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Immunoprecipitation, Western Blot; Rat |
Publishing research using PGCB-201AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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PGCB-201AP | |||
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P-PGCB | |||
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PGCB-BIOTIN | |||
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PC-PGCB | |||
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