General Information |
|
Product |
RIPK3 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope |
Verified Applications |
ELISA, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Human, Pig, Monkey |
Immunogen |
Synthetic peptide taken within amino acid region 461-511 on human Receptor-interacting Serine/Threonine-protein kinase 3 protein. |
Accession # |
NCBI: NP_006862.2 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.66-0.68 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Cell membrane, Mitochondrion |
Expression |
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. |
Structure |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
Alternative Nomenclature |
Receptor interacting protein 3 antibody Receptor interacting serine threonine kinase 3 antibody Receptor-interacting protein 3 antibody RIP 3 antibody RIP like protein kinase 3 antibody RIPK 3 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
RIPK3-301AP | |||
|
P-RIPK3.301 | |||
|
RIPK3.301-BIOTIN | |||
|
PC-RIPK3 | |||
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