General Information

Product

DRP1 Antibody

Description

Dynamin-related Protein 1 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

D. Melanogaster, Human, Mouse, Rat

Immunogen

Synthetic peptide within 450-490 on human DRP1 protein.

Accession #

GenBank: BAC06576.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:450

Protein

Uniprot #

Q8K1M6

Overview

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism.

Molecular Function

GTP-binding, Lipid-binding, Nucleotide-binding

Subcellular Location

Golgi apparatus; Peripheral membrane protein; peroxisome; Mitochondrion outer membrane; Clathrin-coated pit; synaptic vesicle membrane

Expression

Expressed in the cerebellum and in several regions of the cerebrum and diencephalon

Structure

Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Oligomerizes in a GTP-dependent manner to form membrane-associated tubules with a spiral pattern. Can also oligomerize to form multimeric ring-like structures.

Alternative Nomenclature

DLP1 antibody

dnm1l antibody

Dnm1p/Vps1p-like protein antibody

dnml1 antibody

DRP1 antibody

DVLP antibody

Dymple antibody

Dynamin 1 like antibody

Dynamin family member proline-rich carboxyl-terminal domain less antibody

Dynamin like protein antibody

Dynamin-like protein 4 antibody

Dynamin-related protein 1 antibody

DYNIV 11 antibody

EMPF antibody

FLJ41912 antibody

HdynIV antibody

VPS1 antibody

General Information

Product

CRMP3 Antibody

Description

Affinity Purified Dihydropyrimidinase related protein 4 Antibody

Verified Applications

ELISA, WB

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Pig, Rat

Immunogen

Synthetic peptide corresponding to amino acids 509-527 of Mouse CRMP3. The peptide was covalently modified to achieve the desired antigenicity before coupling to carrier protein.

Sequence:

PAKPGSGTQARASCSGKIS

Accession #

NCBI: NP_006417.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:450

Protein

Uniprot #

O14531

Overview

Necessary for signaling by class 3 semaphorins and subsequent remodeling of cytoskeleton.  Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Molecular Function

Axon guidance; pyrimidine nucelobase catabolic process; Nervous system development

Subcellular Location

Cytoplasm

Structure

Homotetramer.

Alternative Nomenclature

Collapsin response mediator protein 3 antibody

DPYSL4 antibody

DRP4 antibody

ULIP 4 antibody

UNC33 like phosphoprotein 4 antibody

General Information

Product

Aph 1b Antibody

Description

Affinity Purified Presenelin-stabiliziation factor-like Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

C. elegans, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8WW43

Overview

Subunit of gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and beta-amyloid precursor protein.

Molecular Function

Notch signaling pathway

Subcellular Location

Membrane; Multi-pass protein

Expression

Weakly expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, heart, and brain.

Structure

Component of gamma-secretase complex.  Interacts with PSEN1 and PSEN2.

Alternative Nomenclature

Anterior pharynx defective 1B like antibody

Gamma secretase subunit APH 1B antibody

Presenilin stabilisation factor like antibody

PRO1328 antibody

PSFL antibody

TAAV 688 antibody

General Information

Product

NPY2R Antibody

Description

Affinity Purified Neuropeptide Y receptor Y2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-381 on human NPY2R protein.

Accession #

GenBank: AAO92062.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P49146

Overview

Receptor for neuropeptide Y and peptide YY

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y Receptor Type 2 antibody

NPY2R antibody

NPYY2 Receptor antibody

Y2 receptor antibody

General Information

Product

NPY5R Antibody Affinity Purified

Description

Affinity Purified Neuropeptide Y receptor type 5 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on NPY5R protein.

Accession #

NCBI: NP_006165.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15761

Overview

Receptor for neuropeptide Y and peptide YY,associated with food intake. Could be involved in feeding disorders.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Brain; hypothalamus.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y receptor type 5 antibody

NPY 5R antibody

NPYY5 antibody

NPYY5-R antibody

Y5 receptor antibody

General Information

Product

PDE7A Antibody

Description

Affinity Purified cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic cyclic peptide common to all PDE7A variants

Accession #

GenBank: AAK57640.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q13946

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Molecular Function

3', 5' -cyclic-AMP phosphodiesterase activity

Subcellular Location

Isoform PDE7A1 : Cytoplasm › cytosol, Isoform PDE7A2: Cytoplasm

Expression

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Structure

Interacts with CBFA2T3

Alternative Nomenclature

HCP 1 antibody

P2A antibody

PDE 7 antibody

PDE1/PDE2 yeast human complement of antibody

PDE7A antibody

Phosphodiesterase 7A antibody

Phosphodiesterase isozyme 7 antibody

Rolipram insensitive phosphodiesterase type 7 antibody

TM 22 antibody

General Information

Product

Phospho-PDE7A Antibody

Description

Affinity Purified High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated Synthetic cyclic peptide common to all PDE7A variants

Specificity

This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P70453

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Molecular Function

Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity

Subcellular Location

Cytoplasm

Expression

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.

Structure

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Alternative Nomenclature

HCP 1 antibody

P2A antibody

PDE 7 antibody

PDE 7A antibody

PDE1/PDE2 yeast human complement of antibody

PDE7 antibody

PDE71 antibody

Phosphodiesterase 7A antibody

Phosphodiesterase isozyme 7 antibody

Rolipram insensitive phosphodiesterase type 7 antibody

TM22 antibody

General Information

Product

PDE7A Antibody

Description

Affinity Purified High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Goat

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic cyclic peptide common to all PDE7A variants

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P70453

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Molecular Function

Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity

Expression

Widely expressed with highest levels in the skeletal muscle.

Structure

Interacts with CBFA2T3.

Alternative Nomenclature

HCP 1 antibody

P2A antibody

PDE 7 antibody

PDE1/PDE2 yeast human complement of antibody

PDE7A antibody

Phosphodiesterase 7A antibody

Phosphodiesterase isozyme 7 antibody

Rolipram insensitive phosphodiesterase type 7 antibody

TM 22 antibody

General Information

Product

Presenilin 2 Antibody Affinity Purified

Description

Affinity Purified Presenilin-2 isoform 1 Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.

Accession #

NCBI:  NP_036618

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.00-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P49810

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.

Molecular Function

Hydrolase, Protease, aspartic-type endopeptidase activity

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein

Expression

Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.

Structure

Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a

Alternative Nomenclature

AD 3LP antibody

AD 4 antibody

AD 5 antibody

Alzheimer disease 4 antibody

CMD1V antibody

E5 1 antibody

Presenilin 2 (Alzheimer disease 4) antibody

PS2 antibody

PSEN 2 antibody

STM2 antibody

General Information

Product

Robo3 Antibody Affinity Purified

Description

Affinity Purified Homer protein homolog 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human RIG1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Z214

Overview

ostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.

Molecular Function

G-protein coupled glutamate receptor binding, identical protein binding, receptor binding

Subcellular Location

Cytoplasm, Cell junction

Expression

Highly expressed in cortex, Purkinje cells of the cerebellum, hippocampus, striatum and olfactory bulb. Isoform 1and isoform 3 are expressed in skeletal and cardiac muscle.

Structure

Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Alternative Nomenclature

HGPPS antibody

HGPS antibody

RB inhibiting gene 1 antibody

Rbig1 antibody

Retinoblastoma inhibiting gene 1 antibody

Rig1 antibody

Roundabout axon guidance receptor homolog 3 antibody

Roundabout like protein 3 antibody