General Information
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Product
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DYRK1 Antibody BIOTIN
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Description
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BIOTIN-Conjugated Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q13627
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Overview
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May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Nucleus speckle
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Expression
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Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
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Structure
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The polyhistidine repeats act as targeting signals to nuclear speckles.
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Alternative Nomenclature
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Dual specificity tyrosine phosphorylation regulated kinase
Dual specificity YAK1-related kinase
DYRK
DYRK1
DYRKA
hMNB
HP86
Minibrain, Drosophila, homolog of
MNB
MNB protein kinase
Mnb protein kinase homolog hp86
MNB protein kinase, Serine/threonine-specific
MNB/DYRK protein kinase
MNBH
MRD7
Protein kinase minibrain homolog
Serine/threonine kinase MNB
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