General Information |
|
Product |
KIRREL Antibody BIOTIN |
Description |
BIOTIN-Conjugated Kin of IRRE-like protein 1 Antibody N-epitope |
Verified Applications |
CM, ELISA, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein. |
Specificity | Extracellular domain. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.45-0.65 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:250 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:250 |
Immunofluorescence |
1:250 |
Immunohistochemistry |
1:250 |
Immunoprecipitation |
1:250 |
Western Blot |
1:250 |
|
|
Uniprot # |
|
Overview |
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
Molecular Function |
Myosin Binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
Structure |
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylate |
Alternative Nomenclature |
FLJ10845 antibody Kin of IRRE like (Drosophila) antibody Kin of IRRE like antibody Kin of irregular chiasm-like protein 1 antibody Kirrel antibody MGC129542 antibody MGC129543 antibody NEPH 1 antibody Nephrin like protein 1 antibody Nephrin related antibody |
Protein information supplied by UniProt
Fabgennix Nephrin Antibody has been used in 1 Publication |
|
Arif, E. et al. “Motor Protein Myo1c Is a Podocyte Protein That Facilitates the Transport of Slit Diaphragm Protein Neph1 to the Podocyte Membrane .”Molecular and Cellular Biology 31.10 (2011): 2134–2150. PMC3133353 |
Confocal Microscopy, Immunofluorescence, Western Blot; Human, Rat
|
Publishing research using NEPH1-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-NEPH1.n | |||
|
NEPH1-101AP | |||
|
NEPH1.n-FITC | |||
|
PC-NEPH1 | |||
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