General Information |
|
Product |
Phospho-KIRREL Peptide |
Description |
Antigenic Blocking Peptide kin of IRRE-like protein 1 Antibody C-epitope |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1. |
Specificity | Intracelular domain. |
Accession # |
NCBI: NP_060710.3 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Uniprot # |
|
Overview |
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
Molecular Function |
Myosin Binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
Structure |
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2. |
Alternative Nomenclature |
FLJ10845 antibody Kin of IRRE like protein 1 antibody Kirrel antibody NEPH1 antibody Nephrin like protein 1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PNEPH-140AP | |||
|
PNEPH-FITC | |||
|
PNEPH-BIOTIN | |||
|
PC-PNEPH | |||
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