PDE4D3 Blocking Peptide

General Information

Product

PDE4D3 Peptide

Description

Antigenic Blocking Peptide cAMP-specific phoshodiesterase HPDE4D3 variant

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant.

Accession #

GenBank: EAW74861.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q08499

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Molecular Function

Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding

Subcellular Location

Apical cell membrane, Cytoplasm, Membrane

Expression

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

Structure

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1).

Alternative Nomenclature

DPDE3 antibody

hPDE4D3 antibody

HSPDE4D antibody

PDE43 antibody

PDE4D antibody

PDE4DN2 antibody

Phosphodiesterase 4D antibody

Phosphodiesterase 4D cAMP-specific antibody

Phosphodiesterase Type 4D3 antibody

STRK1 antibody