General Information |
|
Product |
SREBP2 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Sterol regulatory element binding protein-2 Antibody |
Verified Applications |
ELISA, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 640-690 on human Sterol regulatory element binding protein-2. |
Accession # |
GenBank: AAA50746.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.64-0.72 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. |
Molecular Function |
Activator, E-box binding, protein C-terminus binding |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein, Golgi apparatus membrane; Multi-pass membrane protein, Cytoplasmic vesicle > COPII-coated vesicle membrane; Multi-pass membrane protein |
Expression |
Ubiquitously expressed in adult and fetal tissues. |
Structure |
Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF13 |
Alternative Nomenclature |
AI608257 antibody bHLHd2 antibody Class D basic helix-loop-helix protein 2 antibody Processed sterol regulatory element-binding protein 2 antibody SREBF 2 antibody SREBP2 antibody Sterol regulatory element-binding transcription factor 2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
SREBF-201AP | |||
|
P-SREBF2 | |||
|
SREBF2-BIOTIN | |||
|
PC-SREBF2 | |||
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