General Information

Product

CCR3 Antibody

Description

Affinity Purified C-C chemokine receptor type 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CCR3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P51677

Overview

Receptor for C-C type chemokine.  Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.

Molecular Function

C-C receptor activity; Host-virus interaction; Receptor; Transducer

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

eosinophils and trace amounts in neutrophils and monocytes

Structure

Binds to HIV-1 Tat.

Alternative Nomenclature

B Chemokine Receptor antibody

CC CKR 3 antibody

CD 193 antibody

CMKBR 3 antibody

CMKBR1L2 antibody

Eosinophil CC Chemokine Receptor 3 antibody

Eosinophil Eotaxin Receptor antibody

Macrophage inflammatory protein 1 alpha receptor like 2 antibody

MIP1 Alpha RL2 antibody

General Information

Product

CCR5 Antibody

Description

Affinity Purified Chemokine receptor type 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.

Accession #

NCBI: AAB65720.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P51681

Overview

Receptor for several inflammatory C-C chemokines.  May play a role in control of granulocytic lineage proliferation or differentiation.

Molecular Function

actin binding; C-C chemokin binding; GPCR; Receptor; Transducer; Host-virus interaction

Subcellular Location

Cell membrane; Mulipass membrane protein.

Expression

Spleen, Thymus, myeloid cell line THP-1, promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells.  Lesser expressed in peripheral blood leukocytes, small intestine and ovary and lung.

Structure

Interacts with PRAF2, HIV-1 surface protein gp120. Glycosylation on Ser-6 is required for binding with CCL4.

Alternative Nomenclature

AM4 7 antibody

CCCKR 5 antibody

CD 195 antibody

CHEMR13 antibody

HIV 1 Fusion Coreceptor antibody

IDDM22 antibody

MIP-1 alpha receptor antibody

General Information

Product

CTLA4 Antibody

Description

Affinity Purified Cytotoxic T-lymphocyte protein 4 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on human CTLA4 protein.

Accession #

GenBank: AAL07473.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P16410

Overview

Inhibitory receptor acting as a major negative regulator of T-cell responses.  The affinity of CTLA4 for its natural B7 family lingands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory correceptor CD28.

Molecular Function

Adaptive Immunity

Subcellular Location

Cell membrane; Single pass type I membrane protein

Expression

Widely expressed with highest levels in lymphoid tissues.  Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory correceptor, on the cell surface following activation.

Structure

Homodimer; disfulfide-linked

Alternative Nomenclature

CD 152 antibody

CD antibody

CD152 antigen antibody

CD152 isoform antibody

Celiac disease 3 antibody

CELIAC3 antibody

CTLA-4 antibody

Cytotoxic T cell associated 4 antibody

Cytotoxic T lymphocyte associated serine esterase 4 antibody

GRD4 antibody

GSE antibody

ICOS antibody

IDDM12 antibody

Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody

General Information

Product

CXCR4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.

Accession #

GenBank:  CAA12166

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P61073

Overview

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Molecular Function

Host-virus Interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome

Expression

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Structure

Monomer. Can form dimers.

Alternative Nomenclature

C-X-C chemokine receptor type 4 antibody

CD184 antibody

Chemokine CXC Motif Receptor 4 antibody

CXCR4 antibody

D2S201E antibody

FB22 antibody

Fusin antibody

HM89 antibody

HSY3RR antibody

LAP 3 antibody

LCR1 antibody

LESTR antibody

Leukocyte derived seven transmembrane domain receptor antibody

Lipopolysaccharide associated protein 3 antibody

Neuropeptide Y receptor Y3 antibody

NPY3R antibody

NPYR antibody

NPYRL antibody

Probable G protein coupled receptor lcr1 homolog antibody

SDF 1 receptor antibody

Stromal cell derived factor 1 receptor antibody

WHIM antibody

General Information

Product

Estrogen Receptor alpha Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human ESTRA protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P03372

Overview

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Molecular Function

Activator, Receptor

Subcellular Location

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Expression

Widely expressed. Isoform 3 is not expressed in the pituitary gland

Structure

Belongs to the nuclear hormone receptor family. NR3 subfamily

Alternative Nomenclature

DKFZp686N23123 antibody

ER alpha antibody

ER antibody

Era antibody

ESR antibody

ESR1 antibody

ESRA antibody

Estradiol receptor antibody

Estrogen nuclear receptor alpha antibody

Estrogen receptor 1 antibody

Estrogen receptor antibody

ESTRR antibody

Major ORF antibody

NR3A1 antibody

Nuclear receptor subfamily 3 group A member 1 antibody

General Information

Product

FSH Antibody

Description

Affinity Purified Follicle stimulating hormone Antibody

Verified Applications

CM, ELISA, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-60 on human FSH protein.

Accession #

GenBank: ABD84005

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

Q1W658

Overview

Binds to activin directly and serves as an activin antagonist.  Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone.

Subcellular Location

Secreted

Structure

Monomer

Alternative Nomenclature

Follicle stimulating hormone receptor isoform 1 antibody

Follitropin receptor antibody

FSH receptor antibody

FSH-R antibody

FSHRO antibody

LGR1 antibody

MGC141667 antibody

MGC141668 antibody

ODG1 antibody

ovarian dysgenesis 1 antibody

General Information

Product

ErbB 2 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-2 isoform b Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 130-180 receptor tyrosine-protein kinase erbB-2 protein.

Accession #

NCBI:  NP_001005862.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04626

Overview

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).

Molecular Function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.

Expression

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Structure

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by hereguline (HRG).

Alternative Nomenclature

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody

c erb B2 antibody

CD340 antibody

cneu antibody

Erb B2 antibody

Erythroblastosis Virus antibody

HER 2 antibody

Herstatin antibody

Metastatic lymph node gene 19 protein antibody

MLN 19 antibody

NEU proto oncogene antibody

Neuro Glioblastoma Derived Oncogene Homolog antibody

NGL antibody

p185 ErbB2 antibody

Proto-oncogene Neu antibody

Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody

TKR1 antibody

verbb2 antibody

General Information

Product

Histone H3 Antibody

Description

Affinity Purified Histone H3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Pedicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human HH3 protein.

Accession #

GeneBank: CAA58540.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P68431

Overview

Core component of nucleosome.Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Molecular Function

DNA-binding

Subcellular Location

Nucleus; Chromosome

Expression

During Sphase, then expression decreases as cell division slows down during the process of differentiation

Structure

Belongs to histone H3 family

Alternative Nomenclature

H3.3B antibody

H3F3A antibody

H3 histone antibody

H3.3A antibody

H3F3 antibody

H3f3b antibody

HIST3H3 antibody

Histone H3 3 pseudogene antibody

PP781 antibody

General Information

Product

Human Lactoferrin Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Full length native protein purified human Lactoferrin.

Accession #

GeneBank: AAA59511

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.8 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P02788

Overview

Iron binding transport proteins which bind two Fe3+ ions in association with the binding of an anion usually bicarbonate. Binds to bacterial surface and is crucial for the bactericidal functions.  Has some antiviral activity against papillomavirus infection.

Molecular Function

DNA binding, Heparin Binding, Iron, metal Binding, Immunity

Subcellular Location

Secreted; Cytoplasmic granule; Nucleus

Expression

Saliva, tears, serum, plasma, urine, distal collecting tubules in the medulla, peripheral blood leukocytes.

Structure

Belongs to transferrin family; Contains 2 transferrin-like domains

Alternative Nomenclature

CKRX antibody

GIG12 antibody

Growth inhibiting protein 12 antibody

HLF2 antibody

Homo sapiens chemokine receptor X antibody

Kaliocin 1 antibody

Lactoferrin antibody

Lactoferroxin A antibody

Lactoferroxin B antibody

Lactoferroxin-C antibody

Lactotransferrin antibody

LF antibody

LTF antibody

Neutrophil lactoferrin antibody

Talalactoferrin alfa antibody

General Information

Product

Helicobacter pylori Antibody

Verified Applications

CM, ELISA, ICC, IF, IP, IHC, WB

Host

Rabbit

Species Cross Reactivity

Helicobacter pylori

Immunogen

Heat killed and denatured Helicobacter pylori extracts

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.80-1.35 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

ELISA

1:5,000

Immunocytochemistry

1:200

Immunofluorescence

1:300

Immunohistochemistry

1:200

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q96CV9

Overview

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection.

Molecular Function

polyubiquitin binding, Rab GTPase binding, protein C-terminus binding

Subcellular Location

Cytoplasm › perinuclear region. Golgi apparatus. Golgi apparatus › trans-Golgi network. Cytoplasmic vesicle ›autophagosome. Cytoplasmic vesicle. Recycling endosome

Expression

Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.

Structure

Interacts with HD, Rab8 (RAB8A and/or RAB8B) (active GTP-bound form), GTF3A, TRAF3, TBK1, MYO6 and TFRC. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increas

Alternative Nomenclature

H. pylori antibody