General Information

Product

TLR13 Antibody

Description

Affinity Purified Toll-like receptor 13 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-480 of mouse TLR13 protein.

Accession #

GenBank: AAI17914.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6R5N8

Overview

Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Molecular Function

protein homodimerization activity, rRNA binding

Subcellular Location

endosome membrane, single-pass type I membrane protein

Alternative Nomenclature

Toll like receptor 13 antibody

General Information

Product

CXCR7 Antibody

Description

Affinity Purified Chemokine (C-X-C motif) receptor 7 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human CXCR7 protein.

Accession #

GenBank: AAH36661

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P25106

Overview

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.

Molecular Function

Cell adhesion, Host-virus interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Early endosome. Recycling endosome

Expression

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue.

Structure

Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.

Alternative Nomenclature

ACKR3 antibody

atypical chemokine receptor 3 antibody

C X C chemokine receptor type 7 antibody

Chemokine orphan receptor 1 antibody

CMKOR1 antibody

CXC R7 antibody

G protein coupled receptor 159 antibody

G protein coupled receptor RDC1 homolog antibody

GPR159 antibody

GPRN1 antibody

RDC 1 antibody

General Information

Product

CXCR6 Antibody

Description

Affinity Purified C-X-C chemokine receptor type 6 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Gorilla, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CXCR6 protein.

Accession #

NCBI:  NP_006555

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

O00574

Overview

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Expressed in lymphoid tissues and activated T cells.

Structure

G-protein coupled receptor 1 family; Transmembrane helix

Alternative Nomenclature

C X C chemokine receptor type 6 antibody

CD186 antigen antibody

Chemokine (C X C motif) receptor 6 antibody

CXCR-6 antibody

G protein coupled receptor bonzo antibody

G protein coupled receptor STRL33 antibody

G protein coupled receptor TYMSTR antibody

General Information

Product

IL12 p35 Antibody Affinity Purified

Description

Affinity Purified Interleukin 12 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 210-260 on human IL12P35 subunit protein.

Accession #

GenBank: AAD16432.1 

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O60595

Molecular Function

interleukin-12 beta subunit binding, protein heterodimerization activity

Alternative Nomenclature

CLMF antibody

CLMF p35 antibody

Cytotoxic lymphocyte maturation factor 1 p35 antibody

IL-12 subunit p35 antibody

IL-12A antibody

Interleukin 12 alpha chain precursor antibody

Interleukin 12 p35 antibody

Natural killer cell stimulatory factor 1 35 kD subunit antibody

NKSF1 antibody

General Information

Product

IL17A Antibody

Description

Affinity Purified Interleukin-17A Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 110-150 on human Interleukin-17A precursor protein.

Accession #

NCBI: NP_002181

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

Q96F46

Overview

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.

Molecular Function

interleukin-17 receptor activity

Subcellular Location

Isoform 1: membrane, single-pass type I membrane protein; Isoform 2: secreted

Expression

Widely expressed.

Alternative Nomenclature

CTLA 8 antibody

Cytotoxic T lymphocyte associated serine esterase 8 antibody

IL-17A antibody

IL17 antibody

Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody

Interleukin 17A antibody

OTTHUMP00000016597 antibody

OTTMUSP00000046003 antibody

General Information

Product

IL17C Antibody

Description

Affinity Purified Pan Interleukin-17 receptor C Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide corresponding to IL17RC protein common to C1, C2, C5, C8, C9, C11, C12 isoforms.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.86-0.94 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8NAC3

Molecular Function

interleukin-17 receptor activity

Subcellular Location

Cell membrane, single-pass type 1 membrane protein (Note: soluble isoforms may be produced)

Expression

Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.

Alternative Nomenclature

CX2 antibody

Cytokine CX2 antibody

IL 17C antibody

IL 21 antibody

Interleukin-17C antibody

MGC126884 antibody

MGC138401 antibody

General Information

Product

IL17RC1 Antibody Affinity Purified

Description

Affinity Purified Interleukin-17 receptor C isoform 2 precursor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 70-120 on IL17RC1 protein common to C2 and C5.

Accession #

NCBI:  NP_703191.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.80-1.1 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8NAC3

Molecular Function

interleukin-17 receptor activity

Subcellular Location

Cell membrane, single-pass type 1 membrane protein (Note: soluble isoforms may be produced)

Expression

Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.

Alternative Nomenclature

CX2 antibody

Cytokine CX2 antibody

IL 17C antibody

IL 21 antibody

Interleukin-17C antibody

MGC126884 antibody

MGC138401 antibody

General Information

Product

IL17RA Antibody

Description

Affinity Purified Interleukin-17 receptor A isoform 1 precursor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-1400 on IL17RA protein.

Accession #

NCBI:  NP_055154.3

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.70-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q96F46

Overview

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.

Molecular Function

interleukin-17 receptor activity

Subcellular Location

Isoform 1: membrane, single-pass type I membrane protein; Isoform 2: secreted

Expression

Widely expressed

Alternative Nomenclature

CANDF5 antibody

CD217 antibody

CTLA8 antibody

HIL 17R antibody

IL 17 receptor A antibody

Interleukin-17 receptor A antibody

MGC10262 antibody

General Information

Product

IL17RB Antibody

Description

Affinity Purified Interleukin-17 receptor B precursor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-400 on IL17RB protein.

Accession #

NCBI:  NP_061195.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9NRM6

Overview

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Molecular Function

Cytokine receptor activity

Subcellular Location

Isoform 1: membrane, single-pass type I membrane protein; Isoform 2: secreted

Expression

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Alternative Nomenclature

CRL 4 antibody

Cytokine receptor CRL4 antibody

EVI 27 antibody

IL 17 receptor B antibody

IL 17 receptor homolog 1 antibody

IL 17B receptor antibody

IL 17Rh1 antibody

MGC5245 antibody

General Information

Product

IL32 Antibody

Description

Affinity Purified Interleukin-32 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 180-234 on human Interleukin-32 (natural killer cells protein 4). The synthetic peptide was post-synthetically modified and conjugated to KLH to achieve desired antigenicity.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.74-0.90 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P24001

Overview

Cytokine that may play a role in innate and adaptive immune responses

Molecular Function

Cytokine

Subcellular Location

extracellular space;membrane

Expression

lymphocytes

Alternative Nomenclature

IL 32alpha antibody

IL 32beta antibody

IL 32delta antibody

IL 32gamma antibody

IL-32 antibody

Interleukin 32 antibody

Interleukin 32 small antibody

Interleukin 32 theta antibody

Interleukin-32 antibody

interleukin-32 eta antibody

Natural killer cell transcript 4 antibody

NK4 antibody

TAIF antibody

TAIFa antibody

TAIFb antibody

TAIFc antibody

TAIFd antibody

Tumor necrosis factor alpha-inducing factor antibody