General Information
|
|
Product
|
AMPK alpha 2 Peptide
|
Description
|
Antigenic Blocking Peptide 5'-AMP-activated protein kinase catalytic subunit alpha-2
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 480-530 on rat 5'-AMP-activated protein kinase catalytic subunit alpha-2 protein.
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
Q09137
|
Overview
|
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.
|
Molecular Function
|
[acetyl-CoA carboxylase] kinase activity
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
AMP-activated protein kinase activity
ATP binding Source: RGD
chromatin binding
histone serine kinase activity
metal ion binding -KW
protein binding
|
Subcellular Location
|
Nucleus, Cytoplasm
|
Expression
|
Skeletal muscle, lower levels in liver, heart and kidney.
|
Structure
|
The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
|
Alternative Nomenclature
|
5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody
ACACA kinase antibody
Acetyl-CoA carboxylase kinase antibody
AMPK alpha 2 chain antibody
AMPK subunit alpha-2 antibody
AMPK2 antibody
AMPKa2 antibody
HMGCR kinase antibody
Hydroxymethylglutaryl-CoA reductase kinase antibody
PRKAA antibody
PRKAA2 antibody
Protein kinase AMP activated alpha 2 catalytic subunit antibody
|
|
|