General Information |
|
Product |
D6 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Atypical chemokine receptor 2 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55-0.75 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Dot Blot |
1:10,000 |
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination. |
Molecular Function |
Chemokine Receptor activity; Scavenger receptor activity |
Subcellular Location |
Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein |
Expression |
Endothelial cells lining afferent lympatics in dermis and lymph nodes. Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine. |
Structure |
C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties. |
Alternative Nomenclature |
ACKR2 antibody Atypical chemokine receptor 2 antibody Chemokine binding protein 2 antibody Chemokine receptor CCR 10 antibody Chemokine receptor CCR 9 antibody CMKBR9 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ACRD6-612AP | |||
|
P-ACRD6M | |||
|
ACRD6M-BIOTIN | |||
|
PC-ACRD6 | |||
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