General Information |
|
Product |
Lck Antibody FITC |
Description |
FITC-Conjugated Lymphocyte cell-specific protein-tyrosine kinase Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 500-539 on human Lymphocyte cell-specific protein-tyrosine kinase. |
Accession # |
GenBank: AAH13200.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. |
Molecular Function |
Kinase, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Cell membrane, Cytoplasm, Membrane |
Expression |
Expressed specifically in lymphoid cells. |
Structure |
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
Alternative Nomenclature |
IMD22 antibody LCK antibody Lck p56 antibody LCK proto-oncogene, Src family tyrosine kinase antibody Leukocyte C-terminal Src kinase antibody LSK antibody Lymphocyte cell specific protein tyrosine kinase antibody Membrane associated protein tyrosine kinase antibody Oncogene lck antibody p56(LSTRA) protein tyrosine kinase antibody p56-LCK antibody pp58 lck antibody Protein YT16 antibody Protooncogene tyrosine protein kinase LCK antibody T lymphocyte specific protein tyrosine kinase p56lck antibody Tyrosine-protein kinase Lck antibody YT 16 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
LCK-101AP | |||
|
LCK-BIOTIN | |||
|
P-LCK | |||
|
PC-LCK | |||
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