General Information
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Product
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Insulin degrading enzyme Antibody BIOTIN-Conjugated
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
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Immunogen
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Synthetic peptide taken within amino acid region 100-150 on human Insulin-degrading enzyme protein.
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Accession #
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GenBank: EAW50092.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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UPI00002289E9
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Overview
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Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
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Molecular Function
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ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease
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Subcellular Location
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Cytoplasm; Cell membrane; Secreted
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Structure
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Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.
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Alternative Nomenclature
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Abeta-degrading protease antibody
FLJ35968 antibody
Ide antibody
insulin protease antibody
Insulin-degrading enzyme antibody
insulinase antibody
insulysin antibody
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