General Information |
|
Product |
ABL1 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Tyrosine-protein kinase ABL1 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 990-1130 of human Isoform IB of Tyorsine-protein kinase ABL1 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. |
Molecular Function |
Kinase, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Cytoplasm > cytoskeleton, Nucleus, Mitochondrion |
Expression |
Widely expressed. |
Structure |
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 proteins kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
Alternative Nomenclature |
Abelson murine leukemia viral oncogene homolog 1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ABL1-101AP | |||
|
ABL1-BIOTIN | |||
|
P-ABL1 | |||
|
PC-ABL1 | |||
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