General Information |
|
Product |
BACE2 B Positive Control |
Description |
Western Blot Positive Control beta-secretase 2 isoform B preproprotein |
Verified Applications |
WB |
Immunogen |
Synthetic peptide taken within amino acid region 350-400 on human BACE2B protein |
Accession # |
NCBI: NP_620477 |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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|
Western Blot |
1:500 |
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|
Uniprot # |
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Overview |
Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase. |
Molecular Function |
Aspartic-type endopeptidase activity. |
Subcellular Location |
Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane |
Expression |
Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate. |
Structure |
Belongs to the peptidase A1 family. |
Alternative Nomenclature |
ALP 56 antibody ASP1 antibody ASP21 antibody Aspartic Like Protease 56kDa antibody Downs Syndrome Region Aspartic Protease antibody DRAP antibody Memapsin-1 antibody Membrane associated aspartic protease 1 antibody Theta-secretase antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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BACE-212AP | |||
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BACE2B-FITC | |||
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P-BACE2B | |||
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BACE2B-BIOTIN | |||
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