General Information

Product

Inhibin alpha Antibody Affinity Purified

Description

Affinity Purified Inhibin alpha chain; Flags Antibody Extreme C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, 86% homology with mouse protein

Immunogen

Synthetic peptide taken within amino acid region 315-365 on human alpha Inhibin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:20,000

ELISA

1:20,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit precursor antibody

IHA antibody

inhA antibody

Inhibin alpha chain antibody

Inhibin alpha chain precursor antibody

General Information

Product

Inhibin alpha Antibody

Description

Affinity Purified Inhibin alpha chain; Flags Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey; 92% homology with mouse protein

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human alpha Inhibin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:20,000

ELISA

1:20,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone.

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit precursor antibody

IHA antibody

inhA antibody

Inhibin alpha chain antibody

Inhibin alpha chain precursor antibody

General Information

Product

Luteinizing Hormone Antibody

Description

Affinity Purified Lutenizing hormone beta subunit Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-136 on human Luteinizing hormone beta subunit.

Accession #

GenBank: AAL69719.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

Q8WXL0

Overview

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Molecular Function

Hormone

Subcellular Location

Secreted

Alternative Nomenclature

CGB 4 antibody

hLHB antibody

Interstitial cell stimulating hormone antibody

Leutropin antibody

LH B antibody

LSH B antibody

Luteinising hormone antibody

Lutropin beta chain antibody

General Information

Product

Luteinizing Hormone Antibody

Description

Affinity Purified Lutenizing hormone beta subunit Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

N-epitope synthetic peptide taken within amino acid region 1-50 on human LH protein.

Accession #

GenBank: CAA76146.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250-1:2,000

Western Blot

1:500

Protein

Uniprot #

O46641

Overview

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Molecular Function

Hormone

Subcellular Location

Secreted

Alternative Nomenclature

CGB 4 antibody

hLHB antibody

Interstitial cell stimulating hormone antibody

Leutropin antibody

LH B antibody

LSH B antibody

Luteinising hormone antibody

Lutropin beta chain antibody

General Information

Product

Prolactin Antibody Affinity Purified

Description

Affinity Purified Prolactin Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

C-epitope specific synthetic peptide taken within amino acid region 100-200 on human Prolactin protein.

Accession #

GenBank:  CAA38264.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:100

Immunohistochemistry

1:100

Western Blot

1:500

Protein

Uniprot #

P01236

Overview

Prolactin acts primarily on the mammary gland by promoting lactation.

Molecular Function

prolactin receptor binding, hormone

Subcellular Location

Secreted

Alternative Nomenclature

Decidual prolactin antibody

Lactogenic Hormone antibody

Luteotropic Hormone antibody

Mammotropin antibody

PRL antibody

General Information

Product

Prolactin Antibody

Description

Affinity Purified Prolactin Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human Prolactin protein.

Accession #

GenBank:  CAA38264.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:100

Immunohistochemistry

1:100

Western Blot

1:500

Protein

Uniprot #

P01236

Overview

Prolactin acts primarily on the mammary gland by promoting lactation.

Molecular Function

prolactin receptor binding, hormone

Subcellular Location

Secreted

Alternative Nomenclature

Decidual prolactin antibody

Lactogenic Hormone antibody

Luteotropic Hormone antibody

Mammotropin antibody

PRL antibody

General Information

Product

TSH beta Antibody Affinity Purified

Description

Affinity Purified Thyroid stimulating hormone, beta Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human TSH beta chain protein.

Accession #

GenBank: AAH69298.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.63-0.69 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

P01222

Overview

Indespensable for the control of thyroid structure and metabolism.

Molecular Function

hormone activity

Subcellular Location

Secreted

Alternative Nomenclature

CHNG4 antibody

Thyroid stimulating hormone beta subunit antibody

Thyrotropin beta subunit antibody

TSHB antibody

General Information

Product

TSH beta Antibody

Description

Affinity Purified Thyroid stimulating hormone, beta Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 human TSH beta chain protein.

Accession #

GenBank: AAH69298.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.63-0.69 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Dot Blot

1:50,000

ELISA

1:50,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Western Blot

1:500

Protein

Uniprot #

P01222

Overview

Indespensable for the control of thyroid structure and metabolism.

Molecular Function

hormone activity

Subcellular Location

Secreted

Alternative Nomenclature

CHNG4 antibody

Thyroid stimulating hormone beta subunit antibody

Thyrotropin beta subunit antibody

TSHB antibody

General Information

Product

TIE2 Antibody

Description

Affinity Purified Tyrosine-protein kinase receptor Tie-1 isoform 2 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 540-590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q02763

Overview

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Integral component of membrane

Expression

Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma. Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family.  Contains protein kinase domain.

Alternative Nomenclature

Angiopoietin 1 receptor antibody

CD202b antibody

Endothelial tyrosine kinase antibody

Endothelium specific receptor tyrosine kinase 2 antibody

Hyk antibody

p140 TEK antibody

TEK antibody

tek tyrosine kinase antibody

TIE 2 antibody

Tunica interna endothelial cell kinase antibody

Tyrosine kinase with Ig and EGF homology domains 2 antibody

Tyrosine protein kinase receptor TEK antibody

Tyrosine protein kinase receptor TIE 2 antibody

Venous malformations multiple cutaneous and mucosal antibody

VMCM 1 antibody

VMCM antibody

General Information

Product

TrkA Antibody

Description

Affinity Purified Tyrosine Receptor Kinase A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on human TrkA protein.

Accession #

GenBank: BAA34355.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04629

Overview

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.  Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Molecular Function

Developmental Protein; Kinase; Receptor; Transferase; Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type I membrane protein; Early & Late endosome membrane

Expression

Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.

Alternative Nomenclature

CIPA antibody

gp140trk antibody

High affinity nerve growth factor receptor antibody

MTC antibody

Neurotrophic tyrosine kinase receptor type 1 antibody

Ntrk1 antibody

Oncogene TRK antibody

p140-TrkA antibody

Slow nerve growth antibody

TRK antibody

Trk-A antibody

TRK1 antibody

TRK1-transforming tyrosine kinase protein antibody

Tropomyosin-related kinase A antibody

Tyrosine kinase receptor A antibody