General Information
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Product
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ULK3 Peptide
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Description
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Antigenic Blocking Peptide Serine/Threonine-protein kinase ULK3 C-epitope
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide corresponding to a region within C terminal amino acids 452-472 of Mouse ULK3, coupled to a carrier protein.
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Accession #
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NCBI: NP_001258064.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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D3ZHP7
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Overview
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Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity).
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Molecular Function
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ATP-binding; Nucleotide-binding; Serine/threonine-protein kinase
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Subcellular Location
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Cytoplasm
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Expression
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Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
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Structure
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Interacts (via protein kinase domain) with SUFU.
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Alternative Nomenclature
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DKFZP434C131 antibody
FLJ90566 antibody
Serine/threonine-protein kinase ULK3 antibody
Ulk3 antibody
unc 51 like kinase 3 (C. elegans) antibody
Unc-51-like kinase 3 antibody
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